green tea

DART-ultraFAIMS-MS: pre-separation with direct ionisation sources DART-ultraFAIMS-MS: pre-separation with direct ionisation sourcesMany mass spec users have highlighted the potential for using FAIMS pre-separation with direct ionisation sources as a gas-phase analog to the LC pre-separation used with electrospray sources. The ultraFAIMS pre-separation should reduce general chemical noise, and may also allow selective transmission of isomers and isobars. We recently coupled our ultraFAIMS-A1 system with the IonSense DART source for proof-of-principle testing, on an Agilent 6230 TOF. This confirmed that the two systems can be coupled without the need for modifications to either instrument.