Research

DART-ultraFAIMS-MS: pre-separation with direct ionisation sources DART-ultraFAIMS-MS: pre-separation with direct ionisation sourcesMany mass spec users have highlighted the potential for using FAIMS pre-separation with direct ionisation sources as a gas-phase analog to the LC pre-separation used with electrospray sources. The ultraFAIMS pre-separation should reduce general chemical noise, and may also allow selective transmission of isomers and isobars. We recently coupled our ultraFAIMS-A1 system with the IonSense DART source for proof-of-principle testing, on an Agilent 6230 TOF. This confirmed that the two systems can be coupled without the need for modifications to either instrument.
Enhance LC–MS determination of drug metabolites in urine using ultraFAIMS Enhance LC–MS determination of drug metabolites in urine using ultraFAIMSThe addition of an ultraFAIMS pre-separation stage into the electrospray ionisation (ESI) source of an LC-ESI-MS improves the qualitative and quantitative of analysis of drug metabolites such as (R/S) ibuprofen 1-beta-O-acyl glucuronide (IAG) in urine, giving lower LOQ, increased LDR, better reproducibility, reduced matrix chemical noise.
Peptide Identification & Structural Elucidation Without Tandem MS Peptide Identification & Structural Elucidation Without Tandem MSUltraFAIMS provides a lower cost alternative to tandem mass spectrometry for experiments that require precursor selection prior to fragmentation by collision induced dissociation (CID). FAIMS-in source CID-MS (FISCID-MS) can be used in conjunction with liquid chromatography and will be of particular interest to those carrying out proteomic analysis of complex biological samples.