Enhance LC–MS determination of drug metabolites in urine using ultraFAIMS Enhance LC–MS determination of drug metabolites in urine using ultraFAIMSThe addition of an ultraFAIMS pre-separation stage into the electrospray ionisation (ESI) source of an LC-ESI-MS improves the qualitative and quantitative of analysis of drug metabolites such as (R/S) ibuprofen 1-beta-O-acyl glucuronide (IAG) in urine, giving lower LOQ, increased LDR, better reproducibility, reduced matrix chemical noise.
Detecting sulfites and SO2 using Lonestar Detecting sulfites and SO2 using LonestarThe Lonestar portable analyzer is able to detect whether Traditional Chinese Medicines (TCM), herbal remedies and alternative medicine products contain sulphites by detecting the presence of trace amounts of sulfur dioxide (SO2). Sulfite sensitivity affects many people making the presence of sulfites in herbal medicines a common concern for consumers.
Dimethyl sulfate gas detection using Lonestar Dimethyl sulfate gas detection using LonestarLonestar can be used as a dimethyl sulfate (DMSO4) gas monitor for ambient air. DMSO4 is a highly toxic but commonly used industrial methylating agent. Lonestar can continuously sample air and raise the alarm if the concentration of DMSO4 rises above a specified threshold level.
Validating Clean in Place Processes Using Lonestar Validating Clean in Place Processes Using LonestarFast validation of Clean in Place (CIP) cycles by monitoring the composition of rinse water is vital to ensure adequate tank cleaning and for the optimisation of production processes in the food, beverage and pharmaceutical sectors. Lonestar delivers rapid, sensitive and accurate monitoring of rinse water helping to reduce water and cleaning product consumption.
Tribromoanisole Detection with Lonestar Tribromoanisole Detection with LonestarLonestar is able to rapidly detect tribromoanisole (TBA) at concentrations as low as 10 ppt. TBA has been identified as a common contaminant in the pharmaceutical, food and wine industries. It has been cited by the FDA as a cause for concern and has been the reason for a number of product recalls.
Pharmaceutical waste water analysis Pharmaceutical waste water analysisWaste water treatment by bacteriological biodegradation is used to treat waste water streams (e.g. pharmaceutical, environmental bioremediation). Excesses of some solvents in the waste water can poison the microbes - reducing their efficiency. Consequently there is value in being able to quickly measure concentrations of these critical solvents so they can be pretreated/diluted to protect the bacteria.
Propofol (2,6-diisopropylphenol) Anaesthetic Detection Propofol (2,6-diisopropylphenol) Anaesthetic DetectionPropofol (2,6-diisopropylphenol, a.k.a. Diprivan) is used as an intravenous general anaesthetic. Existing measurement techniques for IV anaesthetics require offline blood samples, making them unsuitable for monitoring anaesthetic depth and for ensuring patient safety. The Owlstone Lonestar Analyzer is able to detect propofol at sub part per billion concentrations in under 10 seconds. In addition, Lonestar is highly portable and can be operated by non-specialists.
Residual Solvent Monitoring with Lonestar Residual Solvent Monitoring with LonestarLonestar is a powerful, easy to use analyzer for accurate, real time identification and monitoring of Class 1, 2 and 3 residual solvents as outlined by The International Conference on Harmonisation (ICH) guidance documents and the United States Pharmacopeia (USP).